佐々木博勇先生が主著者の下垂体関連論文がFrontiers in Endocrinologyに掲載されました。
Subcutaneous transplantation of human embryonic stem cells-derived pituitary organoids
Hiroo Sasaki, Hidetaka Suga, Kazuhito Takeuchi, Yuichi Nagata, Hideyuki Harada, Tatsuma Kondo, Eiji Ito, Sachi Maeda, Mayu Sakakibara, Mika Soen, Tsutomu Miwata, Tomoyoshi Asano, Hajime Ozaki, Shiori Taga, Atsushi Kuwahara, Tokushige Nakano, Hiroshi Arima, Ryuta Saito
2023 Mar 2;14:1130465. doi: 10.3389/fendo.2023.1130465. eCollection 2023.
前澤聡先生の定位的頭蓋内脳波(SEEG)に関する総説(special topic)がpublishされました。
Clinical Impacts of Stereotactic Electroencephalography on Epilepsy Surgery and Associated Issues in the Current Situation in Japan.
Maesawa S, Ishizaki T, Mutoh M, Ito Y, Torii J, Tanei T, Nakatsubo D, Saito R.
Neurol Med Chir (Tokyo). 2023 Mar 31. doi: 10.2176/jns-nmc.2022-0271. Online ahead of print.
種井隆文先生の脊髄刺激(SCS)に対する新しい方法の症例報告がpublishされました。
Relief of Central Poststroke Pain Affecting Both the Arm and Leg on One Side by Double-independent Dual-lead Spinal Cord Stimulation Using Fast-acting Subperception Therapy Stimulation: A Case Report.
Tanei T, Maesawa S, Nishimura Y, Nagashima Y, Ishizaki T, Mutoh M, Ito Y, Saito R.
NMC Case Rep J. 2023 Feb 9;10:15-20. doi: 10.2176/jns-nmc.2022-0336.
赤堀翔先生が主著者の頚椎前方手術に関する原著論文がWorld Neurosurgeryにpublishされました。
Comparative Study of Anterior Transvertebral Foraminotomy and Anterior Cervical Discectomy and Fusion for Unilateral Cervical Spondylotic Radiculopathy
Sho Akahori, Yusuke Nishimura, Kaoru Eguchi, Yoshitaka Nagashima, Ryo Ando, Takayuki Awaya, Takafumi Tanei, Masahito Hara, Tokumi Kanemura, Masakazu Takayasu, Ryuta Saito
World Neurosurg. 2023 Mar;171:e516-e523. doi: 10.1016/j.wneu.2022.12.053. Epub 2022 Dec 14.
頚椎前方手術に関する原著論文
吉川哲史先生が主著者の脊椎外傷に関する原著論文がNeurologia medico-chirurgicaにpublishされました。
Evaluation of Posterior Ligamentous Complex Injury in Thoracolumbar Burst Fractures: Correlation Analysis of CT and MRI Findings
Satoshi Yoshikawa, Yusuke Nishimura, Yoshitaka Nagashima, Hiroshi Ito, Takahiro Oyama, Tomoya Nishii, Tomomi Gonda, Hiroshi Ryu, Kei Nomura, Masahito Hara, Masakazu Takayasu, Howard J Ginsberg, Tokumi Kanemura, Ryuta Saito
Neurol Med Chir (Tokyo). 2023 Mar 1. doi: 10.2176/jns-nmc.2021-0390.
脊椎外傷に関する原著論文
加藤寛之先生が主著者の松果体腫瘍の播種に関する症例報告論文がJournal of Neurosurgery Case Lessonsにpublishされました。
Pineal parenchymal tumor of intermediate differentiation with late spinal dissemination 13 years after initial surgery: illustrative case
Hiroyuki Kato, Takafumi Tanei, Yusuke Nishimura, Yoshitaka Nagashima, Motonori Ishii, Tomoya Nishii, Nobuhisa Fukaya, Takashi Abe, Ryuta Saito
J Neurosurg Case Lessons. 2023 Feb 13;5(7):CASE22475. doi: 10.3171/CASE22475. Print 2023 Feb 13.
松果体腫瘍の播種に関する症例報告
深谷宜央先生が主著者の脊髄刺激療法に関する症例報告論文がNMC Case Report Journalにpublishされました。
Spinal Cord Stimulation for Neuropathic Pain following a Spinal Cord Lesion with Past Spinal Surgical Histories Using a Paddle Lead Placed on the Rostral Side of the Lesion: Report of Three Cases
Nobuhisa Fukaya, Takafumi Tanei, Yusuke Nishimura, Masahito Hara, Nobuhiro Hata, Yoshitaka Nagashima, Satoshi Maesawa, Yoshio Araki, Ryuta Saito
NMC Case Rep J. 2022 Oct 13;9:349-355. doi: 10.2176/jns-nmc.2022-0218. eCollection 2022.
脊髄刺激療法に関する症例報告
阿部節先生が主著者の頚椎椎間板ヘルニアに関する症例報告がCureusにpublishされました。
True Angina Pectoris Immediately After Cervical Disc Herniation Surgery for Preoperative Cervical Angina Symptoms: A Case Report
Takashi Abe, Takafumi Tanei, Yusuke Nishimura, Ryuta Saito
Cureus. 2022 Aug 23;14(8):e28313. doi: 10.7759/cureus.28313. eCollection 2022 Aug.
頚椎椎間板ヘルニアに関する症例報告
永島吉孝先生が主著者の脊髄上衣腫の画像変化に関する症例報告論文がWorld Neurosurgeryにpublishされました。
Magnetic Resonance Imaging Scans of Cervical Spinal Cord Ependymoma with Changing Radiological Features over a Short Period of Time
Yoshitaka Nagashima, Yusuke Nishimura, Ryuta Saito
World Neurosurg. 2022 Nov;167:95-97. doi: 10.1016/j.wneu.2022.08.116. Epub 2022 Aug 31.
脊髄上衣腫の画像変化に関する症例報告
粟屋尭之先生が主著者の腰部脊柱管狭窄への片側侵入両側除圧術の成績に関する原著論文がWorld Neurosurgeryにpublishされました。
Radiological Analysis of Minimally Invasive Microscopic Laminectomy for Lumbar Canal Stenosis with a Focus on Multilevel Stenosis and Spondylolisthesis
Takayuki Awaya, Yusuke Nishimura, Kaoru Eguchi, Yoshitaka Nagashima, Ryo Ando, Sho Akahori, Satoshi Yoshikawa, Shoichi Haimoto, Masahito Hara, Masakazu Takayasu, Ryuta Saito
World Neurosurg. 2022 Aug;164:e224-e234. doi: 10.1016/j.wneu.2022.04.079. Epub 2022 Apr 25.
腰部脊柱管狭窄への片側侵入両側除圧術の成績に関する原著論文
永島吉孝先生が主著者の骨粗鬆症性椎体骨折と脊柱管狭窄症の治療に関するテクニカルノート論文がSurgical Neurology Internationalにpublishされました。
Unilateral laminotomy for bilateral decompression and balloon kyphoplasty to decompress lumber canal stenosis aggravated by osteoporotic vertebral compression fractures: A technical note
Yoshitaka Nagashima, Yusuke Nishimura, Motonori Ishii, Tomoya Nishii, Nobuhisa Fukaya, Takahiro Oyama, Takashi Abe, Hiroyuki Kato, Eisuke Tsukamoto, Takafumi Tanei, Ryuta Saito
Surg Neurol Int. 2022 Nov 18;13:538. doi: 10.25259/SNI_971_2022. eCollection 2022.
骨粗鬆症性椎体骨折と脊柱管狭窄症の治療に関するテクニカルノート
永島吉孝先生が主著者の骨化くも膜炎に関する症例報告論文がNMC Case Report Journalにpublishされました。
Diagnosis and Treatment Strategies for Arachnoiditis Ossificans Following Subarachnoid Hemorrhage: A Case Report
Yoshitaka Nagashima, Yusuke Nishimura, Hiroshi Ito, Tomoya Nishii, Takahiro Oyama, Ryuta Saito
NMC Case Rep J. 2022 Sep 15;9:295-299. doi: 10.2176/jns-nmc.2022-0036. eCollection 2022.
骨化くも膜炎に関する症例報告
雄山隆弘先生が主著者の脊髄神経鞘腫に関する症例報告論文がSurgical Neurology Internationalにpublishされました。
Laminectomy triggers symptomatic growth of spinal schwannoma in a patient with schwannomatosis
Takahiro Oyama, Yusuke Nishimura, Yoshitaka Nagashima, Tomoya Nishii, Masahito Hara, Masakazu Takayasu, Ayako Sakakibara, Ryuta Saito
Surg Neurol Int. 2022 Jun 23;13:261. doi: 10.25259/SNI_453_2022. eCollection 2022.
脊髄神経鞘腫に関する症例報告
橋田美紀先生主著者のtumefactive perivascular spaceの自然消失に関する症例報告論文がnagoya journal of medical scienceにpublishされました。
Spontaneous regression of asymptomatic tumefactive perivascular spaces in the anterior temporal lobe Miki Hashida, Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Toshiaki Taoka, Hisashi Kawai, Ryuta Saito
Nagoya J Med Sci. 2022 Aug;84(3):678-685. doi: 10.18999/nagjms.84.3.678.
tumefactive perivascular spaceの自然消失に関する症例報告
永島吉孝先生が主著者の脊髄腫瘍と遺伝子変異に関するレビュー論文がNeurospineにpublishされました。
Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors
Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Junya Yamaguchi, Shoichi Haimoto, Fumiharu Ohka, Masakazu Takayasu, Ryuta Saito
Neurospine. 2022 Jun;19(2):262-271. doi: 10.14245/ns.2244168.084. Epub 2022 May 16.
脊髄腫瘍と遺伝子変異に関するレビュー
石川晃司郎先生のシーメンスとの共同研究である4D-DSAに関する論文がpublishされました。
Ishikawa K, Nishihori M, Izumi T, et al.
Four-dimensional digital subtraction angiography for the vascular anatomical diagnosis of dural arteriovenous malformation: Comparison with the conventional method [2022 Dec 15].
Interv Neuroradiol. 2022;15910199221145526. doi:10.1177/15910199221145526
後藤峻作先生のカネカメディックスとの共同研究である透明コイルを用いたvitro実験に関する論文がpublishされました。
Goto S, Izumi T, Nishihori M, et al.
Efficacy of comparing coil behavior and distribution using the silicone aneurysm model: difference of coil distribution in the early filling stage.
Nagoya J Med Sci. 2022;84(4):762-771. doi:10.18999/nagjms.84.4.762
佐々木博勇先生が主著者の内視鏡関連論文がActa Neurochirurgicaに掲載されました。
The importance of preserving the superior hypophyseal artery infundibular branch in craniopharyngioma surgery
Hiroo Sasaki, Kazuhito Takeuchi, Yuichi Nagata, Kuniaki Tanahashi, Akihiro Mizuno, Hideyuki Harada, Yugo Kishida, Tadashi Watanabe, Tetsuya Nagatani, Ryuta Saito
2022 Nov 10. doi: 10.1007/s00701-022-05415-3.
竹内和人先生が主著者の内視鏡関連論文がActa Neurochirurgicaに掲載されました。
Efficacy and safety of the endoscopic 'wet-field' technique for removal of supratentorial cavernous malformations
Kazuhito Takeuchi, Yuichi Nagata, Kuniaki Tanahashi, Yoshio Araki, Akihiro Mizuno, Hiroo Sasaki, Hideyuki Harada, Keishi Ito, Ryuta Saito
2022 Oct;164(10):2587-2594. doi: 10.1007/s00701-022-05273-z. Epub 2022 Jun 22.
竹内和人先生が主著者の内視鏡関連論文がActa Neurochirurgicaに掲載されました。
Quick and simple dural threading technique for transsphenoidal surgery - dural tenting, haemostasis and skull base reconstruction
Kazuhito Takeuchi, Yuichi Nagata, Kuniaki Tanahashi, Ryuta Saito
2022 Jun;164(6):1619-1622. doi: 10.1007/s00701-022-05227-5. Epub 2022 May 2.
竹内和人先生が主著者の内視鏡関連論文がWorld Neurosurgeryに掲載されました。
Endoscopic Trans-Mini-Cylinder Biopsy for Intraparenchymal Brain Lesions
Kazuhito Takeuchi, Fumiharu Ohka, Yuichi Nagata, Sachi Maeda, Kuniaki Tanahashi, Yoshio Araki, Taiki Yamamoto, Hiroo Sasaki, Akihiro Mizuno, Hideyuki Harada, Ryuta Saito
2022 Sep 9;S1878-8750(22)01273-6. doi: 10.1016/j.wneu.2022.08.147.
永田雄一先生が主著者の内視鏡関連論文がNeurologia medico-chirurgicaに掲載されました。
Modified Shoelace Dural Closure with Collagen Matrix in Extended Transsphenoidal Surgery
Yuichi Nagata, Kazuhito Takeuchi, Hiroo Sasaki, Akihiro Mizuno, Hideyuki Harada, Kuniaki Tanahashi, Yoshio Araki, Ryuta Saito
2022 Apr 15;62(4):203-208. doi: 10.2176/jns-nmc.2021-0355. Epub 2022 Mar 16.
木部祐士先生、本村和也先生の脳腫瘍関連の論文がScientific Reportsに掲載され、プレスリリースを行いました。
名古屋大学大学院医学系研究科脳神経外科学（齋藤竜太教授）の本村和也（もとむらかずや）准教授と木部祐士（きべゆうじ）大学院生（筆頭著者）の研究グループは、稀な腫瘍である画像上限局型の病巣を形成する IDH野生型組織学的びまん性星細胞種の臨床的および分子生物学的特徴について報告しました。
IDH野生型の神経膠腫は組織学的に低悪性度腫瘍（びまん性星細胞種）の所見であっても膠芽腫と同様に IDH変異型のびまん性星細胞腫と比較して予後不良とされています。このような IDH野生型びまん性星細胞種は脳の広範囲に浸潤するタイプが多く、限局型の病巣を形成することは稀であり、そのような腫瘍の臨床的経過・分子生物学的特徴は明らかになっていません。
本研究では画像上限局型の病巣を形成した IDH野生型組織学的びまん性神経膠腫 5 例の臨床経過・分子生物学的特徴をまとめて報告しました。症例は全て女性で、平均発症年齢は 55.4 歳、発生部位は前頭葉 2 例、島回 3 例でした。初回手術の病理組織学的診断は全てびまん性星細胞腫（grade II）でした。後療法は行わず経過観察をしたところ、わずか平均 12.4 カ月（5.8-28.7 カ月）で再発を認めました。再発時の病理は 4 例が膠芽腫（grade IV）で 1 例が膠肉腫（grade IV）で、全例摘出腔内に限局した造影病変での再発でした。全例再摘出術を施行し、放射線化学療法（Stupp regimen）を施行しました。初回手術検体の遺伝子解析を行い、5 例全例IDH1,2が野生型であることが確認されました。そのうち 4 例で膠芽腫に特徴的なTERT プロモーターの変異を認めました。残りの 1 例でCDKN2A homozygous deletionを認め、再発までの期間は 5.8 カ月と最も短期間でした。これらのことから、限局した病変で病理所見上の特徴は低悪性度神経膠腫と酷似していても、IDH野生型びまん性星細胞種は非常に予後不良であり、分子生物学的解析による診断が重要であると考えられます。
本研究成果は 2023 年 1 月 16 日付（日本時間 2023 年 1 月 16 日 19 時）『Scientific Reports』オンライン版に掲載されました。
山口純矢先生、大岡史治先生が筆頭著者の脳腫瘍関連の論文がCancer Medicineに掲載され、プレスリリースを行いました。
名古屋大学大学院医学系研究科脳神経外科学の山口純矢 医員、大岡史治 講師、齋藤竜太 教授の 研究グルーフは、85 症例の中枢神経系原発悪性リンパ腫(PCNSL)の遺伝子異常と予後の統合解析を行い、CD79B Y196 変異は、PCNSLに対するR-MPV療法 の良好な反応性の予測因子になることを同定いたしました。また、PCNSLで特異的、かつ高頻度にみられるMYD88 L265P変異を診断マーカーとして、MYD88 L265P変異とCD79B Y196変異を同時に、かつ迅速に解析するシステムを開発し、PCNSLの分子診断と治療反応性の予測を90 分以内で判定することが可能となりました。 PCNSL は高齢者に好発する稀な悪性脳腫瘍のひとつですが、近年の高齢化に伴いその発生数は増加しています。化学療法の発達に伴い、PCNSLの予後は改善してきておりますが、その希少性からまとまった症例数での長期的な予後や予後因子に関したデータは十分ではありませんでした。そこでR-MPV 療法で治療を受けた85 症例のPCNSL の遺伝子異常と予後の解析を行い、R-MPV療法は従来のHD-MTX療法に比較して長期予後に優れ、またCD79B Y196変異を持つ症例では、R-MPV療法の感受性が良く、予後が良好であることがわかりました。このCD79B Y196変異による予後改善効果は、HD-MTX 療法を受けた症例では観察されず、CD79B Y196 変異はR-MPV療法の良好な反応性の予測因子であることがわかりました。さらに、MYD88 L265P 変異を診断マーカーとして、MYD88 L265P変異とCD79B Y196変異の同時迅速解析系を開発し、PCNSL の分子診断と治療反応性の予測を、少量の腫瘍検体から90分以内に判定することが可能になりました。 本研究で得られた成果により、PCNSLの迅速、かつ正確な分子診断、CD79B Y196 変異の有無を軸にした治療の層別化が期待されます。
本研究成果は「Cancer Medicine」(2022 年 12 月 7 日電子版)に掲載されました。
西川知秀先生が筆頭著者の脳腫瘍関連の論文がBrain Tumor Pathology に掲載されました。
Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas
Nishikawa, T. Watanabe, R. Kitano, Y. Yamamichi, A. Motomura, K. Ohka, F. Aoki, K. Hirano, M. Kato, A. Yamaguchi, J. Maeda, S. Kibe, Y. Saito, R. Wakabayashi, T. Kato, Y. Sato, S. Ogino, T. Natsume, A. Ito, I.
Brain Tumor Pathol. 2022 Jan;39(1):14-24.
DOI: 10.1007/s10014-021-00418-x. Epub 2021 Nov 26.
本村和也先生が主著者の脳腫瘍関連の論文がFrontiers in Neurologyに掲載されました。
Supratotal Resection of Gliomas With Awake Brain Mapping: Maximal Tumor Resection Preserving Motor, Language, and Neurocognitive Functions
Motomura, K. Ohka, F. Aoki, K. Saito, R.
Front Neurol. 2022 May 12;13:874826.
DOI: 10.3389/fneur.2022.874826. eCollection 2022.
木部祐士先生、棚橋邦明先生の脳腫瘍関連の論文がBMC Neurologyに掲載されました。
Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review
Yuji Kibe, Kuniaki Tanahashi, Kazuhiro Ohtakara, Yuka Okumura, Fumiharu Ohka, Kazuhito Takeuchi, Yuichi Nagata, Kazuya Motomura, Sho Akahori, Akihiro Mizuno, Hiroo Sasaki, Hiroyuki Shimizu, Junya Yamaguchi, Tomohide Nishikawa, Kenji Yokota & Ryuta Saito
BMC Neurology volume 22, Article number: 223 (2022)
PMID: 35717180
PMCID: PMC9206259
DOI: 10.1186/s12883-022-02749-4
山口純矢先生が筆頭著者の脳腫瘍関連の論文がNMC case report journalに掲載されました。
Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
Yamaguchi, J. Motomura, K. Ohka, F. Aoki, K. Tanahashi, K. Hirano, M. Chalise, L. Nishikawa, T. Shimizu, H. Natsume, A. Wakabayashi, T. Saito, R.
NMC Case Rep J. 2021 Nov 2;8(1):747-753.
DOI: 10.2176/nmccrj.cr.2021-0120. eCollection 2021.
本村和也先生が筆頭著者の脳腫瘍関連の論文がJournal of Neurosurgeryに掲載されました。
Intraoperative seizure outcome of levetiracetam combined with perampanel therapy in patients with glioma undergoing awake brain surgery
Motomura, K. Chalise, L. Shimizu, H. Yamaguchi, J. Nishikawa, T. Ohka, F. Aoki, K. Tanahashi, K. Hirano, M. Wakabayashi, T. Natsume, A.
J Neurosurg. 2021 Jan 22:1-10.
DOI: 10.3171/2020.8.JNS201400.
本村和也先生が筆頭著者の脳腫瘍関連の論文がJournal of Neuro-Oncologyに掲載されました。
Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping
Motomura, K. Chalise, L. Ohka, F. Aoki, K. Tanahashi, K. Hirano, M. Nishikawa, T. Yamaguchi, J. Shimizu, H. Wakabayashi, T. Saito, R.
J Neurooncol. 2021 Jun;153(2):361-372.
DOI: 10.1007/s11060-021-03776-w. Epub 2021 May 19.
Dr. Taiki Yamamoto`s paper on a novel neuro endoscopic technique has been published in the Neurosurgical Review.
A novel endoscopic ventriculocisternostomy and stenting technique with a transparent acryl puncture needle for a trapped temporal horn: a technical report and literature review.
Taiki Yamamoto, Kazuhito Takeuchi, Yuichi Nagata, Akihiro Mizuno, Hideyuki Harada, Ryuta Saito.
Neurosurg Rev. 2021 Oct 2. doi: 10.1007/s10143-021-01634-x. Online ahead of print PMID: 34599431
s10143-021-01634-x.pdf
Dr. Shiraishi Daimon`s paper on traumatic spine surgery has been published in Neurospine.
Clinical and Radiological Clues of Traumatic Craniocervical Junction Injuries Requiring Occipitocervical Fusion to Early Diagnosis
https://pubmed.ncbi.nlm.nih.gov/35000327/
Daimon Shiraishi, Yusuke Nishimura, Isaac Aguirre-Carreno, Masahito Hara, Satoshi Yoshikawa, Kaoru Eguchi, Yoshitaka Nagashima, Hiroshi Ito, Shoichi Haimoto, Yu Yamamoto, Howard J Ginsberg, Masakazu Takayasu, Ryuta Saito
Neurospine . 2021 Dec;18(4):741-748.
DOI: 10.14245/ns.2142860.430
Dr. Tomoya Nishii`s paper on brain tumor has been published in the Journal of Spine Surgery.
Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature
Tomoya Nishii, Yoshitaka Nagashima, Yusuke Nishimura, Hiroshi Ito, Takahiro Oyama, Mamoru Matsuo, Ayako Sakakibara, Satoko Shimada, Ryuta Saito
Journal of Spine Surgery 7(4),532-539,2021
Dr. Tomomi Gonda`s article on spinal cord tumor has been published in NMC Case Report Journal.
https://doi.org/10.2176/nmccrj.cr.2021-0086
Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration
Tomomi GONDA, Yoshitaka NAGASHIMA, Yusuke NISHIMURA, Hiroshi ITO, Tomoya NISII, Takahiro OYAMA, Masahito HARA, Ryuta SAITO
NMC Case Report Journal 8, 705–711, 2021
Dr. Yoshitaka Nagashima`s article on surgical procedure of spinal cord tumor has been published in Nagoya Journal of Medical Science.
Piecemeal resection of aggressive vertebral hemangioma using real-time navigation-guided drilling technique
https://pubmed.ncbi.nlm.nih.gov/34916728/
Yoshitaka Nagashima, Yusuke Nishimura, Shoichi Haimoto, Kaoru Eguchi, Takayuki Awaya, Ryo Ando, Sho Akahori, Masahito Hara and Atsushi Natsume
Nagoya J Med Sci. 2021 Nov;83(4):861-868.
doi: 10.18999/nagjms.83.4.861.
Dr. Yoshitaka Nagashima`s article on spinal cord tumor has been published in the Cells.
Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury
https://pubmed.ncbi.nlm.nih.gov/34685506/
Yoshitaka Nagashima, Yusuke Nishimura, Fumiharu Ohka, Kaoru Eguchi, Kosuke Aoki, Hiroshi Ito, Tomoya Nishii, Takahiro Oyama, Masahito Hara, Yotaro Kitano, Hirano Masaki, Toshihiko Wakabayashi, Atsushi Natsume
Cells . 2021 Sep 24;10(10):2525.
doi: 10.3390/cells10102525.
Dr. Kenji Uda`s article on deep vessel suture technique has been published in the Neurosurgical Review.
Advantages of petrosectomy for superficial temporal artery to superior cerebellar artery bypass based on three-dimensional distance measurements using cadaver heads
https://pubmed.ncbi.nlm.nih.gov/34735687/
Kenji Uda, Kuniaki Tanahashi, Takashi Mamiya, Fumiaki Kanamori, Kinya Yokoyama, Masahiro Nishihori, Takashi Izumi, Yoshio Araki, Ryuta Saito
Neurosurg Rev. 2021 Nov 4.
PMID: 34735687
DOI: 10.1007/s10143-021-01686-z
https://link.springer.com/article/10.1007/s10143-021-01686-z
Dr. Yoshio Araki`s article on anastomosis technique for pediatric Moyamoya disease has been published in the Neurosurgical Review.
Challenging direct bypass surgery for very young children with moyamoya disease: technical notes
https://pubmed.ncbi.nlm.nih.gov/34718925/
Yoshio Araki, Kenji Uda, Kinya Yokoyama, Fumiaki Kanamori, Michihiro Kurimoto, Yoshiki Shiba, Takashi Mamiya, Masahiro Nishihori, Kazuhito Takeuchi, Kuniaki Tanahashi, Yuichi Nagata, Yusuke Nishimura, Sho Okamoto, Masaki Sumitomo, Takashi Izumi, Ryuta Saito
Neurosurg Rev. 2021 Oct 31.
PMID: 34718925
DOI: 10.1007/s10143-021-01685-0
https://link.springer.com/article/10.1007%2Fs10143-021-01685-0
Dr. Kenji Uda`s article on neurovascular malformation has been published in NMC Case Report Journal.
Coexistence of a Dural Arteriovenous Fistula and Pial Arteriovenous Malformation Sharing a Common Drainer https://www.jstage.jst.go.jp/article/nmccrj/8/1/8_cr.2020-0349/_html/-char/ja
Kenji UDA, Takashi IZUMI, Fumiaki KANAMORI, Kinya YOKOYAMA, Tetsuya TSUKADA, Masahiro NISHIHORI, Kazunori SHINTAI, Sho OKAMOTO, Yoshio ARAKI
p. 557-563, 1, Number8, 2021 doi: https://doi.org/10.2176/nmccrj.cr.2020-0349
Dr. Fumiaki Kanamori and Dr. Kinya Yokoyama`s article on Moyamoya disease has been published in the Neurosurgical Focus.
Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair
Fumiaki Kanamori , Kinya Yokoyama, Akinobu Ota, Kazuhiro Yoshikawa, Sivasundaram Karnan, Mikio Maruwaka, Kenzo Shimizu, Shinji Ota, Kenji Uda, Yoshio Araki, Sho Okamoto, Satoshi Maesawa, Toshihiko Wakabayashi, Atsushi Natsume
Neurosurg Focus. 2021 Sep;51(3):E3.
doi: 10.3171/2021.6.FOCUS20870.
https://pubmed.ncbi.nlm.nih.gov/34469870/
Nagoya University Neurosurgery made a press release after Dr. Shintaro Yamazaki and Dr. Fumiharu Ohka`s original research was published in Neuro-Oncology.
World`s first experiment model of meningioma was established by Nagoya University group. This patient derived organoid model will pave ways to better pathological analysis leading to novel therapies.
Graduate student Shintaro Yamamoto, associate professors Fumiharu Ohka and Atsushi Natsume`s research group from Nagoya University (Research Dean Kenji Kadomatsu; Neurosurgery Chairman Ryuta Saito) successfully established a novel meningioma organoid model from patient derived tumor. Meningioma is the most common primary brain tumor. While the standard therapy including surgery and radiation usually bring favorable outcomes, malignant cases and incomplete resection even in benign cases may recur multiple times leading to bad survival prognosis. Although recent research has led to identification of molecular abnormalities associated with tumor proliferation, no molecular targeting drugs have been developed dues to the lack of elucidation of tumor proliferation mechanism. So far it had been difficult to conduct pathological analyses due to the lack of proper cell line and animal models for research. Recently, organoid models using various 3D cancer culture has received limelight as promising research models. We were able to establish meningioma organoid models from all the cultures in every case using this culture technique for the first time in the world.
We focused on the abnormal expression of FOXM1 gene in rapidly growing malignant meningioma and verified the influence of FOXM1 in tumor proliferation using the meningioma organoid model. We identified the change in tumor proliferation in the organoid model by altering FOXM1 gene by over expression or knockdown and demonstrated the potential of FOXM1 as a novel therapeutic target by inhibiting tumor growth using a combination of FOXM1 inhibitor and radiation therapy. This experiment model is expected to aid in the elucidation of detailed pathology of meningioma and development of novel therapeutic strategies. The results of this study were published online in “Neuro-Oncology” on July 2, 2021.
Nagoya University Neurosurgery made a press release after Dr. Kosuke Aoki`s brain tumor research was published in Cancer Research.
Elucidation of optimal therapy to prevent malignant transformation in brain tumor- optimal treatment strategies tailored for each case revealed by mathematical modelling.
Dr. Kosuke Aoki (Specially designated assistant professor), Atsushi Natsume (Associate professor) of Nagoya University graduate school of medicine Department of Neurosurgery along with Dr. Haeno Hiroshi (Specially Designated Associate Professor) of Tokyo University revealed the optimal therapeutic approach to prevent malignant transformation of low grade IDH-Mutant Gliomas (Grade II) using mathematical analysis.
Diffuse glioma, one of the most common brain tumors, is refractory to treatment. Low grade IDH mutant gliomas, an initially slowly growing tumor common among people in their 30s and 40s, becomes life threatening after malignant transformation. Surgical resection along with chemotherapy and radiation therapy control tumor growth. However, these therapies are also reported to trigger malignant transformation. The optimal timing of treatment to prevent malignant transformation is yet to be understood.
In this study, we performed a comprehensive gene mutation analysis and constructed a mathematical model for tumor progression based on treatment history and MR Images of 276 low grade glioma patients from 10 different institutions in Japan.
These analyses revealed that the number of tumor cell genetic mutations is strongly associated with the risk of malignant transformation and that postoperative treatments such as chemotherapy and radiotherapy suppress tumor growth while increasing the risk of malignant transformation per cell. Moreover, we were able to show that the ideal treatment to prevent malignant transformation differs for each case. We found that starting chemotherapy and radiotherapy immediately after surgery is the optimal treatment to prevent malignant transformation in small tumors (less than 50cc in volume at the time of first surgery). On the other hand, while chemotherapy and radiation immediately after surgery is the optimal treatment in most cases of larger tumors (more than 50cc), postoperative treatment accelerates malignant transformation in cases with specific gene mutation patterns and with insufficient surgical resection. Moreover, we were able to demonstrate that early diagnosis and early treatment are extremely important in preventing this malignant transformation. The result of this study is a very important finding that has clarified the optimal treatment strategy for each patient to prevent malignant transformation of low-grade IDH mutant gliomas and improve survival.
This study was published in the online version of “Cancer Research” on July 31, 2021.
This research was supported by the Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research on Innovative Areas, and Grant-in-Aid for Young Scientists, Grant-in aid from the Japan Brain Foundation, National Cancer Center Research and Development Fund, and a research grant from SRL, and H.U. Group Research Institute.
Nagoya University Neurosurgery made a press release after the research paper on awake surgery and neuroscience by Dr. Kazuya Motomura (co-first author) was published in the jourmal “Cortex”.
Elucidation of mechanism of change in interoception and emotion before and after brain tumor surgery: Interdisciplinary research of brain and mind neurosurgery and cognitive neuroscience.
Research group of Professor Satoshi Umeda and Dr. Yuri Terasawa (Associate Professor) of Keio University Department of Psychology and Dr. Kazuya Motomura (Associate Professor, Nagoya University Department of Neurosurgery) tested the emotion recognition ability of brain tumor patients before and after tumor removal and showed that the decline in this ability is associated with a decline in the ability to perceive changes in the internal state of the body (interoceptive sensation).
Although various studies have been conducted on the relationship between the function of the brain and the mind, how the perception of one's own emotions, such as happiness, sadness, and anger, changes when an actual brain region is damaged or removed remains unknown. From the results of previous research, it has been suggested that stimulation and removal of the insular cortex (insular gyrus), which is closely related to the perception of changes in the body's internal states such as heartbeat and respiration, leads to changes in the recognition of excitatory emotions such as anger. In this study, In this study, we examined the role of the insular cortex in cardiac interoception and recognizing emotions from facial expressions (task involving recognition of facial expression from photographs of faces) by comparing them pre- and post-operatively in 18 patients with tumors involving the insular gyrus. Comparison of the results of these tasks before and after surgery demonstrated significant associations between the changes in interoceptive accuracy and sensitivity to expressions of anger and happiness. This suggests that the insular cortex functions as a neural substrate for interoceptive sensations, which are information from within the body and supports the recognition of emotions such as anger and joy. It also suggests that the bodily sensations such as throbbing and nervousness are essential for experiencing rich emotions. It can also be conceived from this study that traumatic and age-related changes in the region in and around the insula may also change perception of emotions.
This study was published in the international journal “Cortex” in April 2021.
Dr. Shotaro Kitano, Assistant Prof. Kosuke Aoki, and Assoc. Prof. Atsushi Natsume`s paper on brain tumors has been published in ACS Applied Materials & Interfaces.
Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds.
Kitano Y, Aoki K, Ohka F, Yamazaki S, Motomura K, Tanahashi K, Hirano M, Naganawa T, Iida M, Shiraki Y, Nishikawa T, Shimizu H, Yamaguchi J, Maeda S, Suzuki H, Wakabayashi T, Baba Y, Yasui T, Natsume A.
ACS Appl Mater Interfaces. 2021 Apr 21;13(15):17316-17329. doi: 10.1021/acsami.1c01754. Epub 2021 Apr 1.
PMID: 33793202
https://pubs.acs.org/doi/10.1021/acsami.1c01754
Dr. Yoshio Araki`s (lead author) article on Moyamoya disease has been published in “Neurosurgical Review. “
Postoperative stroke and neurological outcomes in the early phase after revascularization surgeries for moyamoya disease: an age-stratified comparative analysis.
Araki Y, Yokoyama K, Uda K, Kanamori F, Kurimoto M, Shiba Y, Mamiya T, Nishihori M, Izumi T, Sumitomo M, Okamoto S, Matsui K, Emoto R, Wakabayashi T, Matsui S, Natsume A.
Neurosurg Rev. 2021 Jan 8. doi: 10.1007/s10143-020-01459-0. Online ahead of print.
PMID: 33415521
https://link.springer.com/article/10.1007/s10143-020-01459-0
Study on nerve regeneration by Associate Professor Atsushi Natsume, Researcher Toshiki Fukuoka (first author), and Researcher Akira Kato (co-first author) has been published in iScience.
Toshiki Fukuoka, Akira Kato, Masaki Hirano, Fumiharu Ohka, Kosuke Aoki, Takayuki Awaya, Alimu Adilijiang, Maeda Sachi, Kuniaki Tanahashi, Junya Yamaguchi, Kazuya Motomura, Hiroyuki Shimizu, Yoshitaka Nagashima, Ryo Ando, Toshihiko Wakabayashi, Dasfne Lee-Liu, Juan Larrain, Yusuke Nishimura, Atsushi Natsume, Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury. iScience . 2021 Jan 20;24(2):102074. doi: 10.1016/j.isci.2021.102074. eCollection 2021 Feb 19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889987/
Dr. Yusuke Nishimura`s paper on spine has been published in NMC Case Report Journal.
Yusuke Nishimura, Masahito Hara, Takayuki Awaya, Ryo Ando, Kaoru Eguchi, Yoshitaka Nagashima, Toshihiko Wakabayashi, Howard J Ginsberg, Possible Double Crush Syndrome Caused by Iatrogenic Acquired Lumbosacral Epidermoid Tumor and Concomitant Sacral Tarlov Cyst. NMC Case Rep J. 2020 Sep 15;7(4):195-199.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538451/
A spine-related paper written by Dr. Yusuke Nishimura as the main author has been published in the Nagoya Journal of Medical Science.
Yusuke Nishimura, Masahito Hara, Atsushi Natsume, Toshihiko Wakabayashi, Howard J Ginsberg, Complete resection and untethering of the cervical and thoracic spinal dermal sinus tracts in adult patients. Nagoya J Med Sci . 2020 Aug;82(3):567-577.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548243/
Dr. Sho Akahori paper on spinal cyst has been published in World Neurosurgery.
Sho Akahori, Yusuke Nishimura, Kaoru Eguchi, Yoshitaka Nagashima, Ryo Ando, Takayuki Awaya, Masahito Hara, Atsushi Natsume, Spontaneous Rupture of a Huge Presacral Tarlov Cyst Leading to Dramatic Neurologic Recovery. World Neurosurg. 2021 Jan;145:306-310
https://www.sciencedirect.com/science/article/abs/pii/S1878875020321069?via%3Dihub
Dr. Takayuki Awaya`s paper on spinal cord tumor has been published in World Neurosurgery.
Takayuki Awaya, Yusuke Nishimura, Kaoru Eguchi, Yoshitaka Nagashima, Ryo Ando, Sho Akahori, Satoshi Yoshikawa, Shoichi Haimoto, Masahito Hara, Atsushi Natsume, Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage. World Neurosurg. 2021 Jan;145:13-18.
https://www.sciencedirect.com/science/article/abs/pii/S1878875020319380?via%3Dihub
Dr. Motoki Ishii`s spine-related paper on thoracic disc herniation has been published in NMC Case Report Journal.
Motonori Ishii, Yusuke Nishimura, Masahito Hara, Kaoru Eguchi, Yoshitaka Nagashima, Takayuki Awaya, Ryo Ando, Shoichi Haimoto, Toshihiko Wakabayashi, Thoracic Disc Herniation Manifesting as Abdominal Pain Alone Associated with Thoracic Radiculopathy. NMC Case Rep J. 2020 Sep 15;7(4):161-165.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538457/
Dr. Yoshitaka Nagashima`s paper on spinal schwannoma has been published in “NMC Case Report Journal.”
Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Takayuki Awaya, Satoshi Yoshikawa, Shoichi Haimoto, Toshihiko Wakabayashi, Masahito, HaraIntraosseous Melanotic Schwannoma in the Sacrum Mimicking Primary Bone Tumor. NMC Case Rep J. 2020 Jun 26;7(3):107-111.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363646/